Market Trends of Global Acute Agitation and Aggression Treatment Industry
This section covers the major market trends shaping the Acute Agitation & Aggression Treatment Market according to our research experts:
Benzodiazepines Segment is Expected to Witness Growth Over the Forecast Period
Benzodiazepines, generally known as "benzos", are a group of drugs that affect the central nervous system (CNS) and are used for several ailments. They affect the brain's gamma-aminobutyric acid-A (GABA-A) receptors, which are specialized receptors. The brain's nerves become less receptive to a stimulus when benzos connect to these receptors, which provides a calming effect. Thus, given the mechanism of benzos for initiating calmness in agitated patients, it is expected to generate demand for benzodiazepines, driving the growth of the segment.
According to the article 'Pharmacologic Management of Acute Agitation in Youth in the Emergency Department' published in August 2022, the benzodiazepines lorazepam, midazolam, and diazepam are used to treat agitation. They are the preferred class of drugs for treating severe anxiety, substance withdrawal, catatonia, and agitation brought on by substance intoxication (excluding alcohol intoxication due to the higher risk of respiratory depression).
In addition, another article, 'Treatment of Agitation with Lorazepam in Clinical Practice: A Systematic Review' published in February 2021, stated that lorazepam is a benzodiazepine that is widely used for the management of acute agitation. Also, as per the conclusion of the above-mentioned study, lorazepam provides consistent results and is safe to use, and can be a clinically effective means of treating acutely agitated patients. Hence, such instances are expected to create demand for the development and approval of benzodiazepines. That is further expected to contribute to segment growth.
Therefore, owing to the above factors mentioned , the segment is expected to witness growth over the forecast period.
North America is Expected to Dominate the Market Over the Forecast Period
Due to increasing geriatric populations prone to various chronic diseases and continuous product developments, North America is one of the major contributors to the studied market.
A rise in the geriatric population in countries across North America is a major contributor to the studied market in the region. For instance, according to America's Health Rankings Senior Report-2022, about 55.6 million people aged 65 years or more were living in the United States in 2020, and this is estimated to reach 73.1 million by 2030, which will account for 21% of the total population. In addition, according to a press release by the government of Canada in April 2022, the number of people aged 65 or more increased drastically to 7 million between 2016 to 2021, and it is the second largest increase in the past 75 years. This age group in 2021 represented approximately 1 in 5 Canadians (19%), up from 16.9% in 2016. As per the source above, the number of people aged 85 and older in Canada increased to 861,000 in 2021 compared to the last decade, and this number is estimated to triple by 2046. As this population is prone to dementia and dementia-related aggressive disorder, the increase in the number of geriatrics demands the availability of treatment options for the same. Thus, it is expected to drive market growth in the region.
Moreover, development activities such as product launches, acquisitions, mergers, and rise in clinical trials among other activities are driving the overall, market growth. For instance, in July 2022, Impel Pharmaceuticals, a commercial-stage pharmaceutical company developing transformative therapies dosed its first subject in a Phase 2a proof-of-concept study of INP105, nasal olanzapine, a widely used atypical, second-generation antipsychotic. INP105 is being developed as an acute treatment for agitation in persons with autism spectrum disorder (ASD) using Impel's proprietary Precision Olfactory Delivery (POD) technology which delivers drugs to the upper nasal space. Such developments are anticipated to contribute to the market growth over the forecast period.
Therefore, owing to the aforesaid factors, North America is expected to dominate the market over the forecast period.
