Market Trends of Adult Malignant Glioma Therapeutics Industry
This section covers the major market trends shaping the Adult Malignant Glioma Therapeutics Market according to our research experts:
The Glioblastoma Multiforme Segment is Expected to Hold a Significant Growth Over The Forecast Period
Glioblastoma Multiforme (GBM) is one of the most aggressive types of brain cancer. The segment is expected to grow during the forecast period owing to the rising number of clinical trial developments and increasing approvals of innovative therapeutics by market players.
The increasing clinical trial developments by government organizations and various market players are significantly contributing to the segment's growth. For instance, as per clinicaltrials.org, 144 trials are ongoing for adult glioblastoma multiforme with the status recruiting, active, not recruiting, enrolling by invitation as of 17th February 2023. The high number of trials for Glioblastoma multiforme of the brain is expected to propel the segment growth during the forecast period.
The rising approvals of innovative therapeutics for the treatment of glioblastoma multiforme are expected to propel the market growth. For instance, in December 2022, the FDA granted Fast Track designation to WP1122 for the treatment of glioblastoma multiforme. The drug is developed by Moleculin Biotech, Inc., which is currently examining collaboration opportunities for the clinical development of WP1122. According to preclinical studies, WP1122 (2-deoxy-D-glucose, or 2-DG) has been shown to increase cellular uptake of 2-DG, increase drug half-life, and increase the ability to cross the blood-brain barrier leading to higher uptake in the brain.
Additionally, in April 2022, CNS Pharmaceuticals, Inc., received approval from the National Agency for the Safety of Medicine and Health Products (ANSM) Competent Authority and from the People Protection Ethics Committee (EC) SUD-EST III (CPP Sud-Est III) in France for the Company's potentially pivotal study of Berubicin for the treatment of recurrent glioblastoma multiforme (GBM). These approvals and launches of advanced therapeutics are expected to propel the segment's growth during the forecast period.
North America is Expected to Hold a Maximum Market Share Over The Forecast Period
North America is expected to dominate the market owing to factors such as the high prevalence of adult malignant glioma, the presence of high funding, and, thereby, ongoing research, along with the high concentration of market players in the region.
According to the American Cancer Society (ACS) 2023 update, the estimated number of brain and spinal cord tumors in the United States, including both adults and children, is 24.8 thousand (14,280 in males and 10,530 in females) in 2023. The most prevalent and malignant brain tumors originating from glial cells are called glioblastomas (GBM). Also, according to the Brain Tumour Registry of Canada 2022 update, the incidence of glioblastoma (GB) is 4 per 100,000 people in Canada. Therefore, the high burden of malignant tumors of the brain or spinal cord in the United States is expected to increase adult glioma incidence, which is further expected to propel the market growth during the forecast period.
Furthermore, according to the National Institute of Health, Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC), May 2022 update, the spending on R&D in the United States for brain cancer was USD 415 million in 2021 and USD 435 million in 2022. The grant provided by the government for the research of brain cancer is expected to develop innovative therapeutics that are further expected to propel market growth in the upcoming years.
Additionally, the rising funding by government and non-government organizations for investigating adult malignant gliomas is expected to propel market growth in the region. For instance, in November 2021, a team of scientists and researchers at the Yale School of Public Health was awarded a USD 13 million grant to study the molecular evolution of lower-grade gliomas, which are slow-growing but malignant brain tumors that primarily affect young adults. These initiatives are expected to develop advanced therapeutics for adult gliomas, thereby propelling the market growth.
Therefore, the factors such as the high burden of malignant brain tumors and funding provided by organizations for R&D are expected to accelerate the market growth in the region during the forecast period.
