Market Size of Global Downstream Processing Industry
Study Period | 2019 - 2029 |
Market Size (2024) | USD 36.06 Billion |
Market Size (2029) | USD 66.72 Billion |
CAGR (2024 - 2029) | 13.10 % |
Fastest Growing Market | Asia Pacific |
Largest Market | North America |
Major Players*Disclaimer: Major Players sorted in no particular order |
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Downstream Processing Market Analysis
The Global Downstream Processing Market size is estimated at USD 36.06 billion in 2024, and is expected to reach USD 66.72 billion by 2029, growing at a CAGR of 13.10% during the forecast period (2024-2029).
The initial phase of the pandemic has had a substantial impact on the growth of the single-use bioprocessing market owing to the significant decline in manufacturing processes and restricted demand and supply of drugs. With the increasing number of COVID-19 cases, the demand for effective drugs and vaccines were increased which has increased the adoption of downstream processing systems and technology by biopharmaceutical companies due to fewer chances of contamination and reduced sterilization tests between the batches. This impacted the market growth during the pandemic.
The factors attributing to the market growth are the increasing demand for the biotechnology sector globally, rising research and development expenditure in biopharmaceutical companies, and an increase in the prominence of contract manufacturing companies.
With the increasing pharmaceutical spending on research and development, adoption of various business strategies, and advanced technology, downstream processing is being increasingly adopted in the biopharmaceutical industry, boosting market growth over the forecast period. According to the data published by the Congressional Budget Office, in 2021, it has been observed that pharmaceutical industries have spent nearly USD 200 billion on research and development in 2020 globally compared to USD 83 million in 2019. Thus, the increasing investment in research and development by the companies further increases the capabilities of the company to adopt innovative bioprocess technologies, resulting in the adoption of continuous downstream processing systems for multicomponent separations, perfusion chromatography systems, high-throughput process development, and high-resolution membrane systems, thereby increasing market growth.
Several advantages offered by downstream processing, such as high efficiency, reduce costs, and generally dominated by chromatographic separations and membrane filtrations are also contributing to the market growth.
Also, the rising utilization of filters in assessing viral inactivation is expected to increase the market growth. For instance, according to an article published in May 2020, titled 'Approaches to Purification, Analysis, and Characterization of Antibody-Based Therapeutics', it has been observed that the final two steps of downstream processing for antibodies often involve the two fundamental biopharmaceutical production technologies of virus filtration and ultrafiltration. Additionally, with current developments like continuous processing and increased monoclonal antibody (mAb) concentrations, virus filters have developed to better meet the needs of the biopharmaceutical industry. Furthermore, as per the same source, parvovirus-retentive filters are now utilized for the development of new mAb processes. Thus, the increased usage of virus filters in the production of antibodies and related biotherapeutics and recent advances in the use of filters is expected to increase the demand for downstream processing which in turn is anticipated to boost the market growth.
However, the high cost of instruments and purification bottleneck are expected to restrain the market growth over the forecast period.
Downstream Processing Industry Segmentation
As per the scope of the report, downstream processing is a part of a bioprocess that includes the recovery and purification of biosynthetic products. The downstream process is found to be an essential part of the manufacturing of vaccines, antibodies, antibiotics, and hormones, such as insulin and human growth hormone. The downstream processing thus includes five stages; solid-liquid separation, intracellular products are released, concentration and chromatography method is used for purification and formulation. The Downstream Processing Market is segmented by Technique (Purification Techniques, Solid-Liquid Separation, and Clarification/Concentration), Product (Chromatography Columns and Resins, Filters, Evaporators, Centrifuges, and Other Products), Application (Antibodies Production, Vaccines Production, Insulin Production, and Other Applications) and Geography (North America, Europe, Asia-Pacific, Middle-East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions globally. The report offers the value (in USD million) for the above segments.
By Technique | |
Purification Techniques | |
Solid-Liquid Separation | |
Clarification/Concentration |
By Product | |
Chromatography Columns and Resins | |
Filters | |
Evaporators | |
Centrifuges | |
Other Products |
By Application | |
Antibodies Production | |
Vaccines Production | |
Insulin Production | |
Other Applications |
Geography | ||||||||
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Global Downstream Processing Market Size Summary
The downstream processing market is poised for significant growth, driven by the increasing demand in the biotechnology sector and heightened research and development activities within biopharmaceutical companies. The market's expansion is further supported by the rising prominence of contract manufacturing companies and the adoption of advanced technologies in the biopharmaceutical industry. The COVID-19 pandemic initially disrupted manufacturing processes but subsequently accelerated the adoption of downstream processing systems due to their advantages in reducing contamination risks and sterilization requirements. This shift has been particularly beneficial in the production of drugs and vaccines, contributing to the market's robust growth trajectory. The market is characterized by the integration of continuous downstream processing systems, high-throughput process development, and advanced membrane systems, which enhance efficiency and reduce costs.
North America is expected to maintain a significant share of the downstream processing market, bolstered by government initiatives and a well-established healthcare infrastructure. The region's market growth is further fueled by substantial investments in biopharmaceutical manufacturing processes and strategic company activities such as mergers and expansions. Key players in the market, including Thermo Fisher Scientific Inc., Merck KGaA, and Sartorius Stedim Biotech S.A., are actively investing in technological advancements and collaborations to enhance their product offerings and maintain competitive advantage. The market's fragmentation is marked by the presence of numerous companies innovating to meet the evolving demands of the biotechnology sector, ensuring continued growth and development in downstream processing technologies.
Global Downstream Processing Market Size - Table of Contents
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1. MARKET DYNAMICS
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1.1 Market Overview
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1.2 Market Drivers
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1.2.1 Growth of Biotechnology Sector Globally
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1.2.2 Rising R&D Expenditure in Biopharmaceutical Companies
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1.2.3 Increase in the Prominence of Contract Manufacturing Organizations
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1.3 Market Restraints
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1.3.1 High Cost of Instruments
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1.3.2 Purification Bottleneck
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1.4 Porter's Five Force Analysis
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1.4.1 Threat of New Entrants
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1.4.2 Bargaining Power of Buyers/Consumers
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1.4.3 Bargaining Power of Suppliers
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1.4.4 Threat of Substitute Products
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1.4.5 Intensity of Competitive Rivalry
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2. MARKET SEGMENTATION (Market Size by Value - USD million)
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2.1 By Technique
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2.1.1 Purification Techniques
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2.1.2 Solid-Liquid Separation
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2.1.3 Clarification/Concentration
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2.2 By Product
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2.2.1 Chromatography Columns and Resins
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2.2.2 Filters
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2.2.3 Evaporators
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2.2.4 Centrifuges
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2.2.5 Other Products
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2.3 By Application
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2.3.1 Antibodies Production
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2.3.2 Vaccines Production
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2.3.3 Insulin Production
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2.3.4 Other Applications
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2.4 Geography
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2.4.1 North America
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2.4.1.1 United States
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2.4.1.2 Canada
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2.4.1.3 Mexico
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2.4.2 Europe
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2.4.2.1 Germany
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2.4.2.2 United Kingdom
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2.4.2.3 France
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2.4.2.4 Italy
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2.4.2.5 Spain
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2.4.2.6 Rest of Europe
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2.4.3 Asia-Pacific
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2.4.3.1 China
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2.4.3.2 Japan
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2.4.3.3 India
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2.4.3.4 Australia
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2.4.3.5 South Korea
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2.4.3.6 Rest of Asia-Pacific
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2.4.4 Middle-East and Africa
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2.4.4.1 GCC
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2.4.4.2 South Africa
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2.4.4.3 Rest of Middle-East and Africa
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2.4.5 South America
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2.4.5.1 Brazil
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2.4.5.2 Argentina
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2.4.5.3 Rest of South America
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Global Downstream Processing Market Size FAQs
How big is the Global Downstream Processing Market?
The Global Downstream Processing Market size is expected to reach USD 36.06 billion in 2024 and grow at a CAGR of 13.10% to reach USD 66.72 billion by 2029.
What is the current Global Downstream Processing Market size?
In 2024, the Global Downstream Processing Market size is expected to reach USD 36.06 billion.