Oligonucleotide Synthesis Market Size
| Study Period | 2019 - 2029 |
| Market Size (2024) | USD 3.42 Billion |
| Market Size (2029) | USD 6.12 Billion |
| CAGR (2024 - 2029) | 12.34 % |
| Fastest Growing Market | Asia Pacific |
| Largest Market | North America |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Need a report that reflects how COVID-19 has impacted this market and its growth?
Oligonucleotide Synthesis Market Analysis
The Oligonucleotide Synthesis Market size is estimated at USD 3.42 billion in 2024, and is expected to reach USD 6.12 billion by 2029, growing at a CAGR of 12.34% during the forecast period (2024-2029).
COVID-19 has impacted the growth of the oligonucleotide synthesis market. The increased demand for COVID-19 diagnostics has, in turn, increased the global demand for oligonucleotide raw materials that form the basis of molecular diagnostic products. In a study published in PLOS One in March 2022, it was observed that the oligonucleotides successfully targetted 5'-polyUs in the coronavirus genome. Also, developing therapeutic COVID-19 medicines employing essential mutational targets, such as the 5'-polyU tract, can lessen the production and spread of new SARS-CoV-2. Such research studies have impacted the demand and adoption for oligonucleotides in drug development, affecting the market growth during a pandemic.
Moreover, various companies are investing in oligonucleotide synthesis, which is expected to increase market growth over the forecast period. For instance, in September 2021, SpeeDx invested in local oligonucleotide manufacturing to reduce supply chain risk and develop a more vital sovereign capacity for critical diagnostics. Such developments are expected to increase the adoption of oligonucleotides in drug development which is anticipated to fuel the market growth over the forecast period.
Other significant factors include the increasing government investments and R&D expenditure in pharmaceutical and biotechnology companies and the use of synthesized oligonucleotides in molecular diagnostics and clinical applications.
There are growing government initiatives for raising funds to develop various genome projects to develop advanced therapeutics to treat multiple chronic and rare diseases. This is expected to increase the demand for oligonucleotides for drug development, boosting the market growth. For instance, in September 2022, the National Institutes of Health invested more than USD 600 million to launch the next stage of its human genome project for the brain. This funding helps to devise new ways to target therapeutics and other molecules to specific brain cell populations.
Additionally, the rising company and government initiatives to boost the development of oligonucleotide-based drug products and the adoption of oligonucleotide technology in the pharmaceutical and biotechnology industry are also expected to increase market growth. For instance, in February 2021, CPI launched a project in the Medicines Manufacturing Innovation Centre to revolutionize the manufacture of oligonucleotides. The Medicines Manufacturing Innovation Centre launched a collaboration with AstraZeneca, Exactmer, Novartis, and UK Research and Innovation to develop a scalable, sustainable, and more cost-effective medicines manufacturing process for oligonucleotides: short strands of synthetic DNA or RNA. This development enhances the production capacity and viability of this exciting new class of medicines and is expected to increase market growth over the forecast period.
Furthermore, the increasing adoption of oligonucleotides in molecular diagnostics and clinical applications contributes to market growth. For instance, in February 2022, researchers at the University of Illinois Urbana developed a new miRNA point-of-care test for cancer detection. The test uses nanoparticles to capture tumor-specific microRNAs (miRNAs) in human serum. In January 2021, Diagenode launched a new small RNA-sequencing solution, D-Plex Small RNA DNBSEQ Kit, compatible with MGI's DNBSEQ sequencers. The kit incorporates unique D-Plex technology for library preparation enabling high performance with ultralow RNA inputs and providing diverse small RNA transcript detection.
Therefore, the studied market is expected to grow over the forecast period owing to the increasing research and development initiatives and the establishment of the facilities. However, the high treatment cost of oligonucleotides and the lack of skilled professionals and research support in undeveloped countries are expected to hinder the growth of the oligonucleotide synthesis market over the forecast period.
Oligonucleotide Synthesis Market Trends
Therapeutic Segment Expected to Register a High CAGR
The therapeutics segment is expected to witness significant growth in the oligonucleotide synthesis market over the forecast period owing to factors such as the increasing prevalence of chronic and rare diseases, along with the growing adoption of oligonucleotides in drug development and rising product launches.
Oligonucleotide therapeutics are classified as therapeutics that use antisense oligonucleotides or small interfering RNAs (siRNAs) to target RNA or protein. Oligonucleotide therapies include decoys that prevent transcription by concentrating on transcription factors, regulate the expression of complementary microRNA (miRNA) to specific mRNAs, and limit the translation of certain proteins from mRNA. For instance, as per an article published in Future Medicine in February 2022, oligonucleotide therapeutics is one of the most adaptable platforms for creating medications for rare diseases.
The growing company's focus on adopting various business strategies, such as collaborations, financing, and others, is also contributing to the market growth. For instance, in January 2022, Ceptur Therapeutics, Inc. successfully acquired USD 75 million in a Series-A financing round led by venBio Partners and Qiming Venture Partners USA to advance RNA therapeutics based on proprietary U1 adaptor technology, a bivalent oligonucleotide that engages sequence-specific mRNA and U1 small nuclear ribonuclear protein. The U1 small nuclear ribonuclear protein is a ubiquitous intracellular machine that regulates transcription and splicing. Utilizing synthetic oligonucleotides that interact with U1 snRNP offers the ability to co-opt the key transcriptome regulator to regulate mRNA in a highly targeted manner.
Furthermore, increasing product launches and approvals are expected to increase the demand for oligonucleotide drugs, propelling the market growth. For instance, in February 2021, the USFDA approved an Amondys 45 (casimersen) injection to treat Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene.
Moreover, various companies are developing oligonucleotide therapeutics, which are expected to increase their adoption in the pharmaceutical and biotechnology industry, bolstering the market growth. For instance, as per clinicaltrials.gov, as of July 2022, TME Therapeutics is developing STNM01, which is being evaluated in a Phase-I clinical study to treat unresectable pancreatic cancer. Also, Nitto Biopharma is developing ND-L02-s0201 under a Phase-II study and is being assessed for idiopathic pulmonary fibrosis (IPF).
Therefore, owing to the factors such as the increasing company activities in adopting various business strategies for developing oligonucleotide-based drugs and rising product launches, the studied segment is anticipated to witness growth over the forecast period.
North America Expected to Occupy a Significant Share in the Studied Market
North America is expected to dominate the market over the forecast period. The factors attributing to the market growth are the rising prevalence of chronic and rare diseases among the population, increasing R&D expenditure by the companies, and the presence of key market players in the region.
According to the Cancer Facts and Figures 2022, over 1.9 million new cancer cases are expected to be diagnosed in the United States in 2022. Also, as per 2022 statistics published by Breastcancer.org, an estimated 287,850 new cases of invasive breast cancer and 51,400 new cases of non-invasive (in situ) breast cancer are expected to be diagnosed in the United States in 2022. The growing burden of cancer among the population raises the need for advanced therapeutics, boosting the demand for oligonucleotide therapeutics and propelling the market growth.
As per the 2022 statistics published by IDF, about 2.9 million people were living with diabetes in Canada in 2021. This number is projected to reach 3.2 million and 3.4 million by 2030 and 2045, respectively. Thus, the expected increase in the diabetic population in the country raises the demand for antisense oligonucleotides in developing antidiabetic agents, as they can reduce the expression of disease-causing genes at the RNA and protein levels. This is anticipated to boost the market growth over the forecast period,
The increasing development of drugs and rising regional product launches are anticipated to fuel market growth. For instance, in January 2022, the USFDA approved inclusion injection (Leqvio), an innovative small inclisiran RNA medicine, to be used with diet and statin therapy in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who require additional lowering of low-density lipoprotein cholesterol (LDL-C).
Furthermore, as per clinicaltrials.gov, as of July 2022, TME Pharma Agis is conducting a Phase II clinical study of Olaptesed Pegol (NOX-A12) combined with pembrolizumab and nanoliposomal irinotecan/5-FU/leucovorin or gemcitabine/nab-paclitaxel in microsatellite-stable metastatic pancreatic cancer patients.
Moreover, the increasing investment by the companies to boost the production of oligonucleotide drugs and facility expansion is contributing to the market growth. For instance, in March 2021, Nitto Denko Corporation revealed its plan to invest about JPY 25 billion (USD 227 million) in its United States-based subsidiary, Nitto Denko Avecia Inc., and other businesses to increase the manufacturing capacity of its therapeutic oligonucleotide business.
Therefore, owing to the factors such as the rising burden of cancer, rising product launches and approvals, growing company activities in conducting clinical trials as well, and increasing company focus on investing in oligonucleotides business are anticipated to fuel the market growth in the North America region over the forecast period.
Oligonucleotide Synthesis Industry Overview
The market is fragmented with the presence of a large number of players adopting various strategies, such as the acquisition of players in emerging markets, distribution partnerships, and collaboration for the development of novel technologies. The companies operating in the oligonucleotide synthesis industry are also expanding and developing their product portfolios, which helps drive the overall market and makes it fairly competitive. Some of the companies which are currently dominating the market are Agilent Technologies, Thermo Fisher Scientific, Merck KGaA, Danaher Corporation, Bio-Synthesis Inc., Eurofins Scientific, Kaneka Corporation (Eurogentec), GenScript, and LGC Limited (LGC Biosearch Technologies).
Oligonucleotide Synthesis Market Leaders
-
Thermo Fisher Scientific
-
Agilent Technologies
-
Merck KGaA
-
Bio-Synthesis Inc
-
Eurofins Scientific
*Disclaimer: Major Players sorted in no particular order
Oligonucleotide Synthesis Market News
- July 2022: WuXi STA, a subsidiary of WuXi AppTec, launched a new large-scale oligonucleotide and peptide manufacturing facility at its Changzhou campus. This new launch enhances its capacity and capability to meet the fast-growing customer needs for oligonucleotide and peptide therapeutics development and manufacturing worldwide.
- April 2022: Bachem entered a strategic collaboration with Eli Lilly & Company to develop and manufacture active pharmaceutical ingredients based on oligonucleotides, a rising new class of complex molecules. Under the agreement, Bachem provides the appropriate engineering infrastructure and expertise to implement Lilly's novel oligonucleotide manufacturing technology.
Oligonucleotide Synthesis Market Report - Table of Contents
1. INTRODUCTION
- 1.1 Study Assumptions & Market Definition
- 1.2 Scope Of The Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
- 4.1 Market Overview
-
4.2 Market Drivers
- 4.2.1 Increasing Government Investments and R&D Expenditure in Pharmaceutical and Biotechnology Companies
- 4.2.2 The Use of Synthesized Oligonucleotides in Molecular Diagnostics and Clinical Applications
-
4.3 Market Restraints
- 4.3.1 High Treatment Cost of Oligonucleotides
- 4.3.2 Lack of Skilled Professionals and Research Support in Undeveloped Countries
-
4.4 Industry Attractiveness - Porter's Five Forces Analysis
- 4.4.1 Threat of New Entrants
- 4.4.2 Bargaining Power of Buyers
- 4.4.3 Bargaining Power of Suppliers
- 4.4.4 Threat of Substitute Products
- 4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION (Market Size by Value - USD Million)
-
5.1 By Product Type
- 5.1.1 Synthesized Oligonucleotide Products
- 5.1.2 Reagents
- 5.1.3 Equipment
- 5.1.4 Services
-
5.2 By Application
- 5.2.1 Research
- 5.2.2 Diagnostics
- 5.2.3 Therapeutics
-
5.3 By End-user
- 5.3.1 Academic Research Institutes
- 5.3.2 Pharmaceutical and Biotechnology Companies
- 5.3.3 Hospital and Diagnostic Laboratories
-
5.4 By Geography
- 5.4.1 North America
- 5.4.1.1 United States
- 5.4.1.2 Canada
- 5.4.1.3 Mexico
- 5.4.2 Europe
- 5.4.2.1 Germany
- 5.4.2.2 United Kingdom
- 5.4.2.3 France
- 5.4.2.4 Italy
- 5.4.2.5 Spain
- 5.4.2.6 Rest of Europe
- 5.4.3 Asia-Pacific
- 5.4.3.1 China
- 5.4.3.2 Japan
- 5.4.3.3 India
- 5.4.3.4 Australia
- 5.4.3.5 South Korea
- 5.4.3.6 Rest of Asia-Pacific
- 5.4.4 Middle East and Africa
- 5.4.4.1 GCC
- 5.4.4.2 South Africa
- 5.4.4.3 Rest of Middle East and Africa
- 5.4.5 South America
- 5.4.5.1 Brazil
- 5.4.5.2 Argentina
- 5.4.5.3 Rest of South America
6. COMPETITIVE LANDSCAPE
-
6.1 Company Profiles
- 6.1.1 Agilent Technologies
- 6.1.2 Thermo Fisher Scientific
- 6.1.3 Merck KGaA
- 6.1.4 Danaher Corporation
- 6.1.5 Bio-Synthesis Inc.
- 6.1.6 Eurofins Scientific
- 6.1.7 Kaneka Corporation (Eurogentec)
- 6.1.8 GenScript
- 6.1.9 LGC Limited (LGC Biosearch Technologies)
- 6.1.10 Maravai Life Sciences
- 6.1.11 Biogen
- 6.1.12 Sarepta Therapeutics, Inc.
- *List Not Exhaustive
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
Oligonucleotide Synthesis Industry Segmentation
Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with a defined chemical structure (sequence).
The Oligonucleotide Synthesis Market is Segmented by Product Type (Synthesized Oligonucleotide Products, Reagents, Equipment, and Services), Application (Research, Therapeutics, and Diagnostics), End-user (Academic Research Institutes, Pharmaceutical and Biotechnology Companies, and Hospital and Diagnostic Laboratories), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions globally. The report offers the value (in USD million) for the above segments.
| By Product Type | Synthesized Oligonucleotide Products | |
| Reagents | ||
| Equipment | ||
| Services | ||
| By Application | Research | |
| Diagnostics | ||
| Therapeutics | ||
| By End-user | Academic Research Institutes | |
| Pharmaceutical and Biotechnology Companies | ||
| Hospital and Diagnostic Laboratories | ||
| By Geography | North America | United States |
| Canada | ||
| Mexico | ||
| By Geography | Europe | Germany |
| United Kingdom | ||
| France | ||
| Italy | ||
| Spain | ||
| Rest of Europe | ||
| By Geography | Asia-Pacific | China |
| Japan | ||
| India | ||
| Australia | ||
| South Korea | ||
| Rest of Asia-Pacific | ||
| By Geography | Middle East and Africa | GCC |
| South Africa | ||
| Rest of Middle East and Africa | ||
| By Geography | South America | Brazil |
| Argentina | ||
| Rest of South America |
Oligonucleotide Synthesis Market Research FAQs
How big is the Oligonucleotide Synthesis Market?
The Oligonucleotide Synthesis Market size is expected to reach USD 3.42 billion in 2024 and grow at a CAGR of 12.34% to reach USD 6.12 billion by 2029.
What is the current Oligonucleotide Synthesis Market size?
In 2024, the Oligonucleotide Synthesis Market size is expected to reach USD 3.42 billion.
Who are the key players in Oligonucleotide Synthesis Market?
Thermo Fisher Scientific, Agilent Technologies, Merck KGaA, Bio-Synthesis Inc and Eurofins Scientific are the major companies operating in the Oligonucleotide Synthesis Market.
Which is the fastest growing region in Oligonucleotide Synthesis Market?
Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).
Which region has the biggest share in Oligonucleotide Synthesis Market?
In 2024, the North America accounts for the largest market share in Oligonucleotide Synthesis Market.
What years does this Oligonucleotide Synthesis Market cover, and what was the market size in 2023?
In 2023, the Oligonucleotide Synthesis Market size was estimated at USD 3.00 billion. The report covers the Oligonucleotide Synthesis Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Oligonucleotide Synthesis Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.
What are the key challenges faced in the Oligonucleotide Synthesis Market?
The key challenges faced in the Oligonucleotide Synthesis Market are a) Strict regulations governing the safety and efficacy of oligonucleotides can create hurdles for market entry and extend development timelines b) Advancements in other gene editing or therapeutic technologies may pose competition for oligonucleotide-based therapies
What are the key challenges faced in the Oligonucleotide Synthesis Market?
The key challenges faced in the Oligonucleotide Synthesis Market are a) Strict regulations governing the safety and efficacy of oligonucleotides can create hurdles for market entry and extend development timelines b) Advancements in other gene editing or therapeutic technologies may pose competition for oligonucleotide-based therapies
Oligonucleotide Synthesis Industry Report
The oligonucleotide synthesis market is experiencing rapid growth, driven by technological advancements in biotechnology and pharmaceutical research that enhance synthesis efficiency, cost-effectiveness, and precision. This growth spans across therapeutic solutions, diagnostics, research, and other molecular biology applications, significantly impacting drug discovery and personalized medicine. The market caters to a variety of end users, including academic research institutes, pharmaceutical and biotechnology companies, and diagnostic laboratories. Market segmentation reveals a focus on products and services in oligonucleotide, reagents, and equipment categories, further subdivided into custom and predesigned oligos. As genomics and personalized medicine advance, demand for these segments continues, supported by regulatory approvals that enhance trust in the safety and efficacy of oligonucleotide therapeutics. Challenges such as high production costs and supply chain vulnerabilities remain. The global market is highly competitive with continuous innovations like rapid gene synthesis services and advanced manufacturing facilities meeting the rising demands in genomics and personalized medicine. For comprehensive insights and future market outlook, get a sample of this industry analysis as a free report PDF download.
