Market Trends of Global Opioid Induced Constipation Industry
This section covers the major market trends shaping the Opioid Induced Constipation Market according to our research experts:
The Mu-opioid Receptor Antagonists in Drug Class Segment are Expected to Hold the Large Market Share in the Opioid-Induced Constipation Market
The Mu-opioid receptor antagonists are expected to account for a large revenue share over the forecast period. This dominance is owing to the availability of various types of products launched by the key players that are suitable for various symptoms in the OIC and the rise in research activities in the segment. A few of the drugs that are readily available in the market for OIC indication are Methylnaltrexone (Relistor), Naldemedine (Symproic), Naloxegol (Movantik), and Alvimopan (Entereg).
Moreover, as per the study titled "Peripheral acting mu-opioid receptor antagonists in the treatment of opioid-induced constipation: a review" published in RESED Journal in September 2020, studies the recently launched Mu-opioid receptor antagonists for their safety and efficacy and concluded that PAMORA had shown efficacy in the treatment of OIC when compared to placebo and in different patient populations, as well as in the case of Naloxegol when compared to laxatives. Metilnaltrexona was studied and approved for patients with advanced cancer pain or other diseases, whereas Alvimopan and Naloxegol were for non-cancer patients. Thus increasing availability of Mu-opioid Receptor Antagonists anticipated the segment growth over the forecast period.
Furthermore, in February 2021, RedHill Biopharma Ltd. signed agreements with Cosmo Pharmaceuticals NV to manufacture two key products; Movantik(μ-opioid receptor antagonist), and RHB-204, currently in a Phase 3 United States study as a stand-alone, first-line orally-administered treatment for pulmonary nontuberculous mycobacteria (NTM) disease.
Additionally, the availability of Relistor in both tablet and subcutaneous injection forms, which is more effective at reversing OIC than other drugs, is expected to drive the segment and contribute to global market revenue over the forecast period.
North America Dominates the Market and Expected to do Same in the Forecast Period.
North America is expected to dominate the overall opioid-induced constipation market throughout the forecast period. Dominance is due to the growing prevalence of various GI disorders among geriatric patients in the United States and a steep rise in the consumption of opioids in Canada in recent years.
According to the Center for Diseases Control and Prevention, November 2021 update, in the United States, the overall opioid dispensing rate in 2020 was 43.3 prescriptions per 100 people. Thus increasing number of OIC prescriptions in the United States boot the market over the forecast period.
Furthermore, according to the study titled "Naldemedine for the treatment of opioid-induced constipation in adults with chronic noncancer pain" published in the Future Medicine In June 2020, Naldemedine appears to be an effective and safe first-line therapy for the treatment of opioid-induced constipation in adults with chronic noncancer pain. Thus, rising product development in the country and several clinical studies are expected to boost the market in the region.
Moreover, product approval and market launch by the key market players are anticipated to drive the market in the country. For instance, in December 2021, Sandoz launched an authorized generic of Narcan (naloxone hydrochloride) Nasal Spray 4 mg in the United States to help people who have overdosed on opioids. Furthermore, the increased availability of advanced healthcare infrastructure and earlier approval of OIC drugs owing to the accelerated drug approval initiative by the United States Food and Drug Administration is also likely to fuel the market growth in this region.
Thus, owing to the abovementioned factors, the market is expected to project growth in the region.
