Transthyretin Amyloidosis Treatment Market Size
| Study Period | 2019 - 2029 |
| Market Size (2024) | USD 5.30 Billion |
| Market Size (2029) | USD 10.90 Billion |
| CAGR (2024 - 2029) | 15.40 % |
| Fastest Growing Market | Asia Pacific |
| Largest Market | North America |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Transthyretin Amyloidosis Treatment Market Analysis
The Transthyretin Amyloidosis Treatment Market size is estimated at USD 5.30 billion in 2024, and is expected to reach USD 10.90 billion by 2029, growing at a CAGR of 15.40% during the forecast period (2024-2029).
The transthyretin amyloidosis treatment market is expected to grow significantly due to the growing geriatric population and risk factors for the amyloid light chain (AL), increasing research and developments (R&D), and raising public disease awareness. Aging is associated with changes in the body's protein structure and function. Transthyretin, a transport protein primarily produced in the liver, undergoes misfolding over time. This misfolding is a critical factor in the development of amyloidosis, where abnormal protein aggregates form and accumulate in tissues, leading to organ dysfunction.
In addition, plasma cell dyscrasia, a condition characterized by abnormal plasma cells, is a known risk factor for amyloid light chain (AL) amyloidosis, a subtype of amyloidosis. The risk of developing plasma cell dyscrasias, including conditions like multiple myeloma, tends to increase as older individuals are more susceptible to abnormalities in plasma cell function and proliferation. For instance, according to the data published by the WHO in October 2023, the population of individuals aged over 65 years is estimated to outnumber those under the age of 15 years in the WHO European region by 2024. This shows a significant number of people in the aging population compared to those of a young age, which may increase the risk of amyloid light chain (AL) amyloidosis, thereby boosting market growth over the study period.
Furthermore, increasing R&D and growing disease awareness are other significant factors driving the growth of the transthyretin amyloidosis treatment market. Pharmaceutical and biotechnology firms are committing substantial resources to R&D to pioneer innovative and targeted treatments for transthyretin amyloidosis. For instance, in February 2024, AstraZeneca reported positive high-level results from the Japan Phase III trial of acoramidis in adults with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). Similarly, in March 2023, Ionis Pharmaceuticals reported the acceptance of a New Drug Application (NDA) for eplontersen, an antisense medicine for the treatment of hereditary transthyretin-mediated amyloid polyneuropathy (ATTRv-PN) by the Food and Drug Administration. These instances show the growing R&D on treating transthyretin amyloidosis, which is expected to have significant growth in the market over the forecast period.
Therefore, the growing geriatric population, risk factors for AL, and increasing R&D activities are some major factors driving the growth of the transthyretin amyloidosis treatment market. However, the high cost associated with this treatment is expected to restrain the market over the forecast period.
Transthyretin Amyloidosis Treatment Market Trends
The Hereditary Transthyretin Amyloidosis Segment is Expected to Hold a Significant Share Over the Forecast Period
Hereditary transthyretin amyloidosis (hATTR) is a rare and severe, heterogeneous multisystem condition with prevalent peripheral (both somatic and autonomic) nervous system impairment due to mutations in the transthyretin (TTR) gene. Hereditary transthyretin amyloidosis (hATTR) is expected to hold a significant market share due to its hereditary characteristics, providing a consistent and identifiable patient base for targeted therapeutic endeavors. The factors driving the growth of this segment include growing awareness of hATTR through awareness programs, growing research investments, and market player strategies like partnerships, product approvals, and launches, which increase the availability of the products.
The increasing disease awareness significantly drives the segment growth as it increases the demand for effective treatments. As healthcare professionals and the general public become more informed about the symptoms, risk factors, and diagnostic advancement related to conditions, there is a growing emphasis on proactive management. For instance, in March 2024, Alnylam Pharmaceuticals Inc. launched the Family Health History Road Trip to encourage conversations between family members about their health history with their doctor to understand their risk for developing hereditary ATTR (hATTR) amyloidosis. This awareness helps in early diagnosis and treatment of the disease using various products, thereby boosting segment growth over the study period.
Furthermore, the strategies of market players, like partnerships and product approvals, increase the availability of the products in the market, thereby boosting segment growth. For instance, in January 2024, AstraZeneca and Ionis selected Orsini Specialty Pharmacy as the exclusive specialty pharmacy partner for WAINUA (eplontersen), an FDA-approved treatment for adults living with hereditary transthyretin-mediated amyloid polyneuropathy. In addition, in August 2022, Alnylam Pharmaceuticals Inc. stated that the FDA approved Onpattro, which can be used for nerve pain caused by hereditary transthyretin amyloidosis. These strategic activities are expected to increase the availability of the products and boost the segment growth over the forecast period.
Therefore, due to the growing awareness and strategic activities of market players, the hereditary transthyretin amyloidosis segment is expected to hold a significant market share over the forecast period.
North America is Expected to Record the Largest Share in the Market Over the Forecast Period
North America is expected to have the largest share in the market due to factors such as advanced healthcare infrastructure and the increasing incidence of transthyretin amyloidosis disease in the region. Established research capabilities, growing investments for research and development, and clinical trial infrastructure are driving the region's market growth.
New investments in developing advanced treatment products for transthyretin amyloidosis (ATTR) are expected to boost the market growth. For instance, in May 2023, the National Institutes of Health (NIH) awarded the Amyloidosis Research Consortium with USD 40,000 toward advancing ATTR amyloidosis drug development. These factors are expected to propel the market growth over the forecast period.
Additionally, growing market player strategies, such as product approvals and positive recommendations from the regulatory authorities, increase the usage of treatment products in the region. For instance, in April 2024, Alnylam Canada ULC received a positive recommendation for reimbursement from the Canadian Agency for Drugs and Technologies in Health (CADTH) for AMVUTTRA (vutrisiran injection). Similarly, in October 2023, AMVUTTRA was authorized for sale in Canada to treat stage 1 or stage 2 polyneuropathy in adult patients with hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). Hence, the positive recommendations and approvals increase the usage and availability of products in the region, thereby boosting the region's market growth over the forecast period.
Transthyretin Amyloidosis Treatment Industry Overview
The transthyretin amyloidosis treatment market is moderately consolidated in nature due to the presence of limited companies operating globally as well as regionally. The competitive landscape includes an analysis of a few international as well as local companies that hold market shares and are well known, including Pfizer Inc., Ionis Pharmaceuticals, Alnylam Pharmaceuticals Inc., Intellia Therapeutics Inc., and BridgeBio Inc.
Transthyretin Amyloidosis Treatment Market Leaders
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Pfizer Inc.
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Ionis Pharmaceuticals
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Alnylam Pharmaceuticals, Inc.
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BridgeBio Inc
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Intellia Therapeutics, Inc.
*Disclaimer: Major Players sorted in no particular order
Transthyretin Amyloidosis Treatment Market News
- April 2024: Alexion, a collaboration partner of Neurimmune and AstraZeneca’s Rare Disease group, initiated the Phase 3 DepleTTR-CM clinical study to assess the efficacy and safety of ALXN2220 for the treatment of transthyretin-mediated amyloid cardiomyopathy (ATTR-CM).
- March 2024: BridgeBio Pharma Inc. partnered with Bayer, wherein BridgeBio granted Bayer an exclusive license to commercialize acoramidis for transthyretin amyloid cardiomyopathy (ATTR-CM) in Europe.
Transthyretin Amyloidosis Treatment Market Report - Table of Contents
1. INTRODUCTION
- 1.1 Study Assumptions and Market Definition
- 1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
- 4.1 Market Overview
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4.2 Market Drivers
- 4.2.1 Growing Geriatric Population and Risk Factors for Amyloid Light Chain (AL)
- 4.2.2 Increasing Research and Development (R&D) and Growing Disease Awareness
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4.3 Market Restraints
- 4.3.1 High Cost Associated with the Transthyretin Amyloidosis Treatment
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4.4 Porter's Five Forces Analysis
- 4.4.1 Threat of New Entrants
- 4.4.2 Bargaining Power of Buyers/Consumers
- 4.4.3 Bargaining Power of Suppliers
- 4.4.4 Threat of Substitute Products
- 4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION (Market Size by Value - USD)
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5.1 By Type
- 5.1.1 ATTR-CM (Transthyretin Amyloid Cardiomyopathy)
- 5.1.2 ATTR-PN (Transthyretin Amyloid Polyneuropathy)
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5.2 By Therapy
- 5.2.1 Targeted Therapy
- 5.2.2 Supportive Therapy
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5.3 By Disease Type
- 5.3.1 Hereditary Amyloidosis
- 5.3.2 Wild-type Amyloidosis
- 5.3.3 Other Disease Type
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5.4 By Distribution Channel
- 5.4.1 Hospitals Pharmacy
- 5.4.2 Retail Pharmacies
- 5.4.3 Other Distribution Channel
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5.5 Geography
- 5.5.1 North America
- 5.5.1.1 United States
- 5.5.1.2 Canada
- 5.5.1.3 Mexico
- 5.5.2 Europe
- 5.5.2.1 Germany
- 5.5.2.2 United Kingdom
- 5.5.2.3 France
- 5.5.2.4 Italy
- 5.5.2.5 Spain
- 5.5.2.6 Rest of Europe
- 5.5.3 Asia-Pacific
- 5.5.3.1 China
- 5.5.3.2 Japan
- 5.5.3.3 India
- 5.5.3.4 Australia
- 5.5.3.5 South Korea
- 5.5.3.6 Rest of Asia-Pacific
- 5.5.4 Rest of the World
6. COMPETITIVE LANDSCAPE
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6.1 Company Profiles
- 6.1.1 Pfizer Inc
- 6.1.2 Ionis Pharmaceuticals
- 6.1.3 Alnylam Pharmaceuticals Inc.
- 6.1.4 BridgeBio Inc
- 6.1.5 Intellia Therapeutics Inc.
- 6.1.6 Prothena
- 6.1.7 Alexion Pharmaceuticals
- 6.1.8 Millennium Pharmaceuticals
- 6.1.9 Corino Therapeutics Inc.
- 6.1.10 Takeda Pharmaceutical Company Limited
- 6.1.11 Oncopeptides
- 6.1.12 SOM BIOTECH
- *List Not Exhaustive
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
** Subject To AvailablityTransthyretin Amyloidosis Treatment Industry Segmentation
As per the scope of the report, transthyretin amyloidosis is a rare disease characterized by the abnormal accumulation of misfolded transthyretin protein, forming amyloid deposits in tissues and organs. Treatment can help manage symptoms, slow disease progression, and improve quality of life.
The transthyretin amyloidosis treatment market is segmented into type, therapy, disease type, distribution channel, and geography. By type, the market is segmented into ATTR-CM (transthyretin amyloid cardiomyopathy) and ATTR-PN (transthyretin amyloid polyneuropathy). By therapy, the market is segmented into targeted therapy and supportive therapy. By disease type, the market is segmented into hereditary amyloidosis, wild-type amyloidosis, and other disease types. Other disease types include AL amyloidosis, AA amyloidosis, and localized amyloidosis. By distribution channel, the market is segmented into hospital pharmacies, retail pharmacies, and other distribution channels. Other distribution channels include specialty pharmacies and online pharmacies. By geography, the market is segmented into North America, Europe, Asia-Pacific, and Rest of the World. The report offers market size and forecast in terms of the value (USD) for the above segments.
| By Type | ATTR-CM (Transthyretin Amyloid Cardiomyopathy) | |
| ATTR-PN (Transthyretin Amyloid Polyneuropathy) | ||
| By Therapy | Targeted Therapy | |
| Supportive Therapy | ||
| By Disease Type | Hereditary Amyloidosis | |
| Wild-type Amyloidosis | ||
| Other Disease Type | ||
| By Distribution Channel | Hospitals Pharmacy | |
| Retail Pharmacies | ||
| Other Distribution Channel | ||
| Geography | North America | United States |
| Canada | ||
| Mexico | ||
| Geography | Europe | Germany |
| United Kingdom | ||
| France | ||
| Italy | ||
| Spain | ||
| Rest of Europe | ||
| Geography | Asia-Pacific | China |
| Japan | ||
| India | ||
| Australia | ||
| South Korea | ||
| Rest of Asia-Pacific | ||
| Geography | Rest of the World |
Transthyretin Amyloidosis Treatment Market Research FAQs
How big is the Transthyretin Amyloidosis Treatment Market?
The Transthyretin Amyloidosis Treatment Market size is expected to reach USD 5.30 billion in 2024 and grow at a CAGR of 15.40% to reach USD 10.90 billion by 2029.
What is the current Transthyretin Amyloidosis Treatment Market size?
In 2024, the Transthyretin Amyloidosis Treatment Market size is expected to reach USD 5.30 billion.
Who are the key players in Transthyretin Amyloidosis Treatment Market?
Pfizer Inc., Ionis Pharmaceuticals, Alnylam Pharmaceuticals, Inc., BridgeBio Inc and Intellia Therapeutics, Inc. are the major companies operating in the Transthyretin Amyloidosis Treatment Market.
Which is the fastest growing region in Transthyretin Amyloidosis Treatment Market?
Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).
Which region has the biggest share in Transthyretin Amyloidosis Treatment Market?
In 2024, the North America accounts for the largest market share in Transthyretin Amyloidosis Treatment Market.
What years does this Transthyretin Amyloidosis Treatment Market cover, and what was the market size in 2023?
In 2023, the Transthyretin Amyloidosis Treatment Market size was estimated at USD 4.48 billion. The report covers the Transthyretin Amyloidosis Treatment Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Transthyretin Amyloidosis Treatment Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.
Transthyretin Amyloidosis Treatment Industry Report
Statistics for the 2024 Transthyretin Amyloidosis Treatment market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Transthyretin Amyloidosis Treatment analysis includes a market forecast outlook for 2024 to 2029 and historical overview. Get a sample of this industry analysis as a free report PDF download.
