Market Trends of Vaccine Adjuvants Industry
Carbohydrate Adjuvants Segment Expected to Witness a Significant CAGR Over The Forecast Period
Carbohydrate adjuvants are safe and biocompatible compounds usable as sustained delivery systems and stimulants of ongoing humoral and cellular immune responses, being especially suitable for the development of vaccines against intracellular pathogens where alum is useless.
The carbohydrate adjuvants segment is expected to grow significantly over the forecast period due to its wide range and use in human vaccines. For instance, as per an article published by Nature Reviews Chemistry in January 2021, carbohydrates play crucial roles in the immune system function and the stimulation of the immune response that can be exploited by the chemistry community. Carbohydrates possess many beneficial properties, such as high biocompatibility and tolerability and a strong safety profile. A variety of natural carbohydrate structures, particularly MPLA and QS-21, have been clinically evaluated as adjuvants and are part of licensed Adjuvant Systems (AS) in human vaccines against HPV (AS04), herpes zoster, and malaria (AS01). Due to these characteristics, the segmental market is expected to grow.
Additionally, in October 2022, the phase 1 test of the novel low-dose influenza vaccine was developed under the INDIGO project, directed by AIGHD. This vaccine combines a new adjuvant, a component used in several vaccines to induce a stronger immune response, with a licensed influenza vaccine at 1/5th of a dose. Such an initiative is expected to drive segmental growth.
Furthermore, a few key market players are developing novel products and technologies to compete with existing products, while others are acquiring and partnering with other companies trending in the market. For instance, in March 2021, Oragenics, Inc. entered into a material transfer agreement with Biodextris Inc. for the use of three intranasal mucosal adjuvants in the company's Terra CoV-2 vaccine against COVID-19. Adjuvants are added to vaccines to enhance their immunogenicity. BDX100, BDX300, and BDX301 are proteosome-based adjuvants comprised of proteins and lipopolysaccharides with improved attributes, including enhanced immune response, manufacturing efficiency, and the benefits of intranasal vaccine administration. Such development is expected to drive the segmental growth.
Thus, owing to the aforementioned factors, such as a wide variety of vaccines, initiatives in the development of vaccines, and strategic development by key players, the carbohydrate adjuvants segment is expected to register healthy growth over the forecast period.
North America Expected to Hold a Significant Market Share Over the Forecast Period
North America is expected to observe significant growth in the market studied during the forecast period. The main factors driving the growth of the vaccine adjuvants market in the North American region are the presence of key market players, the availability of advanced technology, and the growing government initiatives to launch various awareness campaigns to increase vaccination. For instance, in January 2021, the United States Department of Health and Human Services (HHS) launched the HPV VAX NOW campaign to increase human papillomavirus (HPV) vaccination rates among young adults ages 18-26. Also, in August 2022, the Government of Canada published the Canadian Immunization Guide Chapter on Influenza and Statement on Seasonal Influenza Vaccine for 2022-2023, which provides updated recommendations regarding the use of seasonal influenza vaccines in Canada. Hence, such an initiative from the government is expected to drive market growth.
Additionally, various strategies such as product approval, launches, agreements, and developments help the market to grow over the study period. For instance, in November 2022, GSK plc reported that the US FDA accepted a Biologics License Application (BLA) and granted priority review for its respiratory syncytial virus (RSV) older adult vaccine candidate. The US FDA grants priority review to applications for vaccines that, if approved, would offer significant improvements in the safety or effectiveness of the treatment or prevention of serious conditions when compared to standard applications.
Therefore, owing to the aforementioned factors, such as several immunization programs, government and non-government initiatives, and increased demand for combined vaccines, the vaccine adjuvants market is expected to augment growth over the analysis period.
